28 research outputs found
Ružica grad
Autorica se interdisciplinarno bavi svim važnim osobinama srednjovjekovnog grada Ružica. Nakon odreÄenja imena i položaja slijedi pregled povijesnih izvora o Ružici od 13. do 18. stoljeÄa, uz upozorenje Äitatelju kako je teÅ”ko odrediti koji se izvori odnose iskljuÄivo na Ružicu, kao i kratak pregled historiografije o Ružici u 19. i 20. stoljeÄu. Dalje se autorica bavi arheoloÅ”kim ostacima lokaliteta Å”to ukljuÄuje pregled faza izgradnje i arhitektonske kamene plastike, uz posebnu pozornost dvorskoj kapeli, koja je jedna od najveÄih u to doba u Slavoniji. Slijedi pregled metalnih i keramiÄkih nalaza, kao i opis dosadaÅ”njih restauratorsko-konzervatorskih zahvata na Ružici. Na koncu se autorica posebno bavi odnosom Ružice i Starog grada ā srednjovjekovne utvrde 2 kilometra južno od Ružice
Ostrogotski nakit u provinciji Dalmaciji
Tijekom 4. i 5. stoljeÄa Rimsko Carstvo doživljava velike turbulencije ponajviÅ”e jer je predmet konstantnih napada barbarskih naroda razliÄite provenijencije. MeÄu takvim narodima pronalaze se i Goti koji se vremenom dijele na dvije velike skupine: Vizigote i Ostrogote. Upravo ovi potonji znaÄajni su za prostor Dalmacije i Panonije jer su u nekoliko vremenskih intervala boravili na istome prostoru
Gothic Ceramic Cups from Rudina
gotiÄke keramiÄke ÄaÅ”e; Rudina; srednji vijek; benediktinci;
srednjovjekovna Slavonij
The use of spectroscopic techniques and chemometric methods in milk technology
Upotreba i primjena spektroskopskih tehnika u prehrambenoj industriji sve viÅ”e raste, a odgovori koje daju olakÅ”avaju rjeÅ”avanje problema u proizvodnji i distribuciji hrane. Primjena spektroskopskih tehnika u mljekarstvu omoguÄava brzu i jeftinu kvalitativnu i kvantitativnu analizu, ali ima i važnu ulogu u opisivanju strukture i teksture mlijeÄnih proizvoda. Kvalitativna i kvantitativna analiza pojedinih sastojaka u složenim sustavima može biti problematiÄna zbog preklapanja spektralnih odgovora, a kao idealan put za rjeÅ”enje tog problema je kemometrija, disciplina koja koristi matematiÄke i statistiÄke metode kako bi oblikovala ili odabrala optimalan mjeriteljski postupak ili eksperiment i omoguÄila dobivanje, maksimalnog broja informacija analizom dobivenih podataka. NajÄeÅ”Äa primjena kemometrije je u analizi skupa podataka i prepoznavanju matematiÄkih modela. Spektroskopske tehnike u kombinaciji s kemometrijskim metodama omoguÄavaju praÄenje procesa i upravljanje kontrolom kvalitete.The use of spectroscopic techniques is on the rise in food industry, and the answers they provide facilitate problem solving in food production and distribution. The application of spectroscopic techniques in dairy technology allows quick and cheap qualitative and quantitative analyses, and is essential in describing the structure and texture properties of dairy products. The qualitative and quantitative analyses of individual components in composite systems may be problematic due to overlaps in spectral responses. An ideal tool to solve this problem is chemometry, a discipline using mathematical and statistical methods to design or choose an optimum measuring procedure or experiment, and to facilitate obtaining the maximum number of information by analysing the data provided. Chemometry is most frequently used in the analysis of data groups and recognition of mathematic models. Spectroscopic techniques combined with chemometric methods make a valuable tool for process monitoring and quality control management
Tekstil u kontekstu održivog razvoja
U suvremenom svijetu ideja održivog razvoja postaje sve popularnijom, a razlog tome je intenzivan razvoj koji nije vodio raÄuna o zaÅ”titi okoliÅ”a i prirodnih resursa te sve veÄa svjesnost ljudi da danaÅ”nji stil života sve viÅ”e ugrožava okoliÅ”. Svakodnevno se spominje održivi razvoj, održivo gospodarstvo, održivo druÅ”tvo, ali i postavlja pitanje koliko i kako pojedinac ili interesna skupina razumije i percipira znaÄenje pojmova održivi razvoj i održivost. Definicije održivog razvoja su razliÄite, a jedna od najprihvatljivijih definicija je ona koju je dala Svjetska komisija za okoliÅ” i razvoj u svom izvjeÅ”Äu u kojem se održivi razvoj definira kao razvoj koji zadovoljava potrebe sadaÅ”njih generacija bez ugrožavanja moguÄnosti buduÄih generacija da zadovolje svoje potrebe. Održivi razvoj može se smatrati otvorenim procesom koji neprekidno vodi do promjena ciljeva i prioriteta, a ima za cilj postizanje održivosti u svim aspektima ljudskog života. Kako se u kontekstu održivog razvoja pozicionira tekstil i percipira tekstilna industrija dovoljno govori Äinjenica da se globalno, tekstilna industrija joÅ” uvijek smatra jednim od najveÄih zagaÄivaÄa okoliÅ”a, a sam tekstil kao sve veÄa i rastuÄa ekoloÅ”ka prijetnja. Da bi se postigla sukladnost tekstila i tekstilne industrije s konceptom održivog razvoja potrebno je principe održivosti ugraditi u sve segmente proizvodnje tekstila, poÄevÅ”i od dizajna (eko-dizajna, zelenog dizajna ili održivog dizajna), koriÅ”tenja održivih sirovina i održivih naÄina proizvodnje pa sve do krajnjeg zbrinjavanja ili odlaganja otpadnih tekstilija na kraju njihova životnog ciklusa
Cancer cell death induced by ruthenium complexes
Summary. Cancer is a complex and often fatal disease characterized by uncontrolled cell division. The most commonly used chemotherapeutics target rapidly dividing cancer cells but, at the same time, damage healthy dividing cells. New metal-based complexes, such as ruthenium complexes, that possess cytotoxic properties, have been developed to overcome these challenges. Ruthenium complexes achieve their antitumor effect mainly by inducing apoptosis. In recent years, induction of other types of cell death, such as ferroptosis and autophagy, was also reported. The dual role of autophagy in cancer cells is a major challenge for the application of metallocomplexes in cancer treatment, either as inducers or inhibitors of autophagy. Also, the effect of ruthenium complexes on other cellular processes such as cell cycle, cell migration, and adhesion are promising approaches in cancer treatment. Our results indicated a significant influence of Ru(II) complexes on these processes in melanoma, cervical and pancreatic cancer. The aim of this review is to summarize the latest data on the effect of ruthenium complexes on different types of cell death
Influence of probiotic cultures addition on the properties of semi-hard eweās cheese
Dodatak probiotiÄkih bakterija u fermentirane mlijeÄne napitke bio je predmet mnogih istraživanja, meÄutim dodatak tih bakterija u sireve, posebno one proizvedene od ovÄjeg mlijeka, nije do sada detaljno istražen. Stoga su u ovom radu proizvedeni probiotiÄki polutvrdi ovÄji sirevi s dodatkom probiotika Bifidobacterium animalis subsp. lactis BB-12 i Lactobacillus acidophilus LA-5. Zrenje sireva se odvijalo 45 dana pri 13 Ā°C i 85 % relativne vlažnosti. Tijekom tog razdoblja odreÄivani su kemijski parametri i provedene su mikrobioloÅ”ke analize proizvedenih probiotiÄkih sireva. Dodatak probiotiÄkih kultura nije znaÄajno utjecao na kemijska i mikrobioloÅ”ka svojstva proizvedenih sireva u usporedbi s kontrolnim sirevima bez dodatka probiotiÄkih kultura. Broj živih probiotiÄkih bakterija održao se na ca 106-107 CFU/g probiotiÄkih sireva tijekom 45 dana zrenja, Å”to je potvrÄeno RAPD metodom. ProbiotiÄki polutvrdi ovÄji sirevi s bakterijom Bifidobacterium animalis subsp. lactis BB-12 su imali sliÄna senzorska svojstva sirevima proizvedenim bez dodatka probiotika, dok je dodatak bakterije Lactobacillus acidophilus LA-5 doveo do poboljÅ”anja okusa polutvrdog ovÄjeg sira. Dobiveni rezultati pokazuju da je polutvrdi ovÄji sir pogodan matriks za primjenu probiotiÄkih kultura Bifidobacterium animalis subsp. lactis BB-12 i Lactobacillus acidophilus LA-5.Addition of probiotic bacteria into fermented milk beverages has been the subject of many studies, however, addition of these bacteria into cheeses, especially the ones made from eweās milk, has not been thoroughly investigated. Therefore, the aim of this study was to produce probiotic semi-hard eweās cheese with addition of probiotic strain Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5. Cheese ripening occurred during 45 days at 13 Ā°C and 85 % of relative humidity. During that period, chemical parameters were determined and microbiological analysis of manufactured probiotic cheeses was performed. Addition of probiotic cultures did not significantly influence the chemical properties and microbiological quality of produced cheeses in comparison with the control cheeses without addition of probiotic cultures. Number of live probiotic bacteria remained at about 106-107 CFU/g of probiotic cheeses during 45 days of ripening, which was confirmed by RAPD method. Sensory properties of probiotic semi-hard eweās cheese with Bifidobacterium animalis subsp. lactis BB-12 were similar to those obtained for cheeses without addition of probiotic, while addition of Lactobacillus acidophilus LA-5 improved the taste of cheeses. Obtained results demonstrated that semi-hard eweās cheese can be an effective matrix for addition of probiotic cultures Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5
ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells
Existing therapies for the treatment of pancreatic cancer are insufficiently effective and accompanied by a large number of side effects. Ruthenium complexes have shown promising antitumor properties in the previous studies 1,2 . Thus, in this investigation, anticancer effects of cis-dichlorobis (2,2'-bipyridyl-4,4'dicarboxylic acid)ruthenium(II) (Ru(II) complex) were evaluated using human pancreatic carcinoma cell lines MIA PaCa-2 and PANC-1 in vitro. Cell viability estimated with SRB assay showed significant antitumor activity of Ru(II) complex on MIA PaCa-2 (~55% of control) 48 and 72 h after treatment. On the other hand, PANC-1 cell viability was decreased only 72 h after treatment with the highest concentration of Ru(II) complex (~70% of control). Seven days after the treatment, analysis of cell survival using clonogenic assay showed a significant decrease in cell growth in both cell lines. Ru(II) complex also caused G 1 cell cycle arrest of ~13% in both cell lines. The highest percentage of apoptotic MIA PaCa-2 cells was obtained 48 h after treatment. In addition, the intracellular level of reactive oxygen species (ROS) was significantly increased, whereas cell migration was reduced in both cell lines. Summarized, Ru(II)complex demonstrates antitumor properties mediated by increased oxidative stress and also implies the antimetastatic potential, which deserves further study